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INSULIN LISPRO+INSULIN LISPRO PROTAMINE

About

INSULIN LISPRO PROTAMINE+INSULIN LISPRO is used to treat type 1 and type 2 diabetes mellitus. In diabetes mellitus type 1, the body does not produce enough insulin to regulate blood sugar levels (glucose). On the other hand, in diabetes mellitus type 2, either the body stops producing enough insulin (the hormone which helps decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, insulin is produced in large amounts, leading to high blood glucose levels.

INSULIN LISPRO PROTAMINE+INSULIN LISPRO contains Insulin lispro and insulin lispro protamine. Insulin lispro is fast-acting insulin, whereas Insulin lispro protamine is an intermediate-acting insulin. INSULIN LISPRO PROTAMINE+INSULIN LISPRO suppresses the production of sugar in the liver and facilitates the reuptake of sugar in the fat and muscle cells; thereby, INSULIN LISPRO PROTAMINE+INSULIN LISPRO ensures rapid and consistent sugar control. 

Your doctor will advise you on how to use the INSULIN LISPRO PROTAMINE+INSULIN LISPRO. In some cases, you may experience hypoglycemia (low blood sugar), itching, mild rash, and injection site reactions like redness or swelling. Most of these side effects of INSULIN LISPRO PROTAMINE+INSULIN LISPRO do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

INSULIN LISPRO PROTAMINE+INSULIN LISPRO is recommended for use by anyone under the age of 18. Consult your doctor before taking INSULIN LISPRO PROTAMINE+INSULIN LISPRO if you are pregnant or breastfeeding. INSULIN LISPRO PROTAMINE+INSULIN LISPRO may cause hypoglycemia, so drive only if you are alert. Avoid alcohol consumption along with INSULIN LISPRO PROTAMINE+INSULIN LISPRO. Keep your doctor informed about your health condition and medications to rule out any interactions. INSULIN LISPRO PROTAMINE+INSULIN LISPRO is a cold chain medicine. It has to be stored in the refrigerator between 2-8°C else its efficiency may be lost. Do not store in the freezer.

Uses of INSULIN LISPRO+INSULIN LISPRO PROTAMINE

Treatment of Type 1 and type 2 Diabetes mellitus

Medicinal Benefits

INSULIN LISPRO PROTAMINE+INSULIN LISPRO belongs to the class of medications called ‘antidiabetics’ primarily used to improve blood sugar control in adults with diabetes mellitus. INSULIN LISPRO PROTAMINE+INSULIN LISPRO is a combination of Insulin lispro and insulin lispro protamine. Insulin is a hormone that works by lowering glucose levels (sugar) in the blood. Insulin lispro is fast-acting insulin. Insulin lispro protamine is an intermediate-acting insulin. INSULIN LISPRO PROTAMINE+INSULIN LISPRO suppresses the production of sugar in the liver and facilitates the reuptake of sugar in the fat and muscle cells; thereby, INSULIN LISPRO PROTAMINE+INSULIN LISPRO ensures rapid and consistent sugar control. INSULIN LISPRO PROTAMINE+INSULIN LISPRO helps prevent the chances of developing serious complications of diabetes, like damage to the retina (retinopathy), damage to the kidney (nephropathy), damage of nerve cells (neuropathy), diabetic foot ulcer, and various complications occurring due to diabetes. INSULIN LISPRO PROTAMINE+INSULIN LISPRO starts to work within 10 minutes after injection, peaks in 2 hours and keeps working for up to 24 hours. Thereby it controls and maintains the glucose levels in the body throughout the day.

Directions for Use

INSULIN LISPRO PROTAMINE+INSULIN LISPRO should be administered subcutaneously (in the upper thigh, abdomen, upper arm, or buttocks). It should never be administered intravenously or in the vein. If you are not well trained to self-administer INSULIN LISPRO PROTAMINE+INSULIN LISPRO, ask your healthcare professional to administer it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of INSULIN LISPRO+INSULIN LISPRO PROTAMINE

  • Hypoglycaemia (low blood sugar level)

  • Injection site reactions

  • Itching

  • Rash

In-Depth Precautions and Warning

Drug Warnings

If you are allergic to any of the contents of INSULIN LISPRO PROTAMINE+INSULIN LISPRO, please inform your doctor. INSULIN LISPRO PROTAMINE+INSULIN LISPRO is not approved for use by anyone under 18. Before taking INSULIN LISPRO PROTAMINE+INSULIN LISPRO, tell your doctor if you have ever had liver/kidney disease or low potassium levels in your blood (hypokalemia). Consult your doctor before taking INSULIN LISPRO PROTAMINE+INSULIN LISPRO if you are pregnant or breastfeeding. Drive only if you are alert as INSULIN LISPRO PROTAMINE+INSULIN LISPRO may cause hypoglycemia. Avoid alcohol consumption along with INSULIN LISPRO PROTAMINE+INSULIN LISPRO. INSULIN LISPRO PROTAMINE+INSULIN LISPRO is a cold chain medicine, and it should be stored in a refrigerator between 2-8°C; otherwise, it may lose its effectiveness. Do not freeze. Keep your doctor informed about your health condition and medicines to rule out any side effects. 

Drug Interactions

Drug-Drug Interactions: INSULIN LISPRO PROTAMINE+INSULIN LISPRO may have an interaction with antidiabetics (e.g. pioglitazone), thyroid hormones (e.g. levothyroxine), blood pressure-lowering medicines (e.g. metoprolol, hydrochlorothiazide, irbesartan, candesartan), bronchodilator (e.g. metaproterenol), pain killer medications (e.g. aspirin), and anti-depressant medications (e.g. sertraline).

Drug-Food Interactions: Avoid alcoholic beverages with INSULIN LISPRO PROTAMINE+INSULIN LISPRO as it may increase or decrease your blood sugar level.

Drug-Disease Interactions: Inform your doctor before taking INSULIN LISPRO PROTAMINE+INSULIN LISPRO if you have or ever had kidney disease, hepatic impairment or liver disease, hypoglycemia (low blood sugar), and hypokalaemia (low potassium level).

Drug-Drug Interactions Checker List:

  • PIOGLITAZONE
  • LEVOTHYROXINE
  • METOPROLOL
  • HYDROCHLOROTHIAZIDE
  • IRBESARTAN
  • CANDESARTAN
  • METAPROTERENOL
  • ASPIRIN
  • SERTRALINE
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      You are recommended not to consume alcohol along with INSULIN LISPRO PROTAMINE+INSULIN LISPRO to avoid unpleasant side effects.

    • Safety Warning

      Pregnancy

      safe if prescribed

      It is safe to use INSULIN LISPRO PROTAMINE+INSULIN LISPRO during pregnancy if prescribed by the doctor. However, consult your doctor if you have any concerns regarding this.

    • Safety Warning

      Breast Feeding

      safe if prescribed

      It is safe to use INSULIN LISPRO PROTAMINE+INSULIN LISPRO by breastfeeding mothers if prescribed by the doctor. However, consult your doctor if you have any concerns regarding this.

    • Safety Warning

      Driving

      caution

      INSULIN LISPRO PROTAMINE+INSULIN LISPRO may cause hypoglycemia (low blood sugar). Therefore, drive only if you are alert.

    • Safety Warning

      Liver

      caution

      INSULIN LISPRO PROTAMINE+INSULIN LISPRO should be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Kidney

      caution

      INSULIN LISPRO PROTAMINE+INSULIN LISPRO should be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Children

      caution

      INSULIN LISPRO PROTAMINE+INSULIN LISPRO is not approved for use by anyone under the age of 18.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Take short, frequent meals. Avoid prolonged fasting.

    • Beware of hypoglycaemia symptoms such as sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience the mentioned symptoms, immediately consume 5-6 candies or three glucose biscuits or three teaspoons of honey/sugar and get in touch with your physician. Make sure to carry these with you at all times, especially for long travels.

    • Avoid drinking alcohol. It increases the risk of hypoglycaemia (decrease in blood sugar which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts various organs).

    • Try to quit smoking.

    • Reduce intake of carbohydrate-rich food like potato, rice, mangoes, bread, sugar, etc.

    • Avoid eating sugary food and prefer food low in calories.

    • When travelling across more than two time zones, you should talk to your doctor concerning adjustments in your insulin schedule.

    Special Advise

    • Your doctor may tell you to have regular potassium level tests as INSULIN LISPRO PROTAMINE+INSULIN LISPRO may cause hypokalaemia (low potassium).

    • You should normally inject INSULIN LISPRO PROTAMINE+INSULIN LISPRO within 15 minutes of a meal.

    • Always use a new sterile needle for each injection.

    Patients Concern

    Disease/Condition Glossary

    Type 1 diabetes mellitus: In type 1 diabetes mellitus, the body does not make insulin (the hormone that helps decrease sugar levels in the blood) to control blood sugar levels.

    Type 2 diabetes mellitus: In type 2 diabetes mellitus, either the body stops producing enough insulin or there is resistance to the action of insulin. As a result, insulin is produced in sufficient amounts but cannot act on the tissues of the organs.

    FAQs

    INSULIN LISPRO PROTAMINE+INSULIN LISPRO is used to treat type 1 and type 2 diabetes mellitus.

    INSULIN LISPRO PROTAMINE+INSULIN LISPRO suppresses the production of sugar in the liver and facilitates the reuptake of sugar in the fat and muscle cells, thereby INSULIN LISPRO PROTAMINE+INSULIN LISPRO ensures rapid and consistent sugar control.

    You should inform your doctor before travelling especially when travelling to a different time zone as a dose adjustment may be required.

    Hypoglycemia refers to low blood sugar levels. INSULIN LISPRO PROTAMINE+INSULIN LISPRO may cause hypoglycemia. The symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. Hypoglycemia can occur if you miss or delay your food, drink alcohol, over-exercise, or take other antidiabetic medicine along with INSULIN LISPRO PROTAMINE+INSULIN LISPRO. Therefore, it is important to monitor blood sugar levels regularly. People with diabetes are advised to keep a quick source of sugar like glucose tablets, chocolate, glucose biscuits, honey, or fruit juice with them. If you experience any of the symptoms of hypoglycemia, consult your doctor.

    In some cases, INSULIN LISPRO PROTAMINE+INSULIN LISPRO can lower the potassium level, leading to a state of hypokalaemia. You may feel dizziness, thirst, and general weakness in this case. So, it is advisable to have regular blood sugar and potassium level check-up.

    Do not stop taking INSULIN LISPRO PROTAMINE+INSULIN LISPRO without consulting your doctor on your own as it may cause an increase in blood glucose levels. Continue taking INSULIN LISPRO PROTAMINE+INSULIN LISPRO for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking INSULIN LISPRO PROTAMINE+INSULIN LISPRO.

    You are recommended to avoid white bread, maida, poori, naan, noodles, biryani, fried rice, corn flakes, cheese, ice creams, milkshakes, beef, pork, sugarcane juice, soft drinks, sweetened health drinks and beverages. Also, avoid mango, seetaphal, jack fruit, fruit salads with ice cream, and fruit-based desserts.

    Taking injection at the same site may cause local irritation, itching and lump formation. Therefore, it is best to avoid taking injections at the same site or maintain a gap of at least one day.

    Maintain a diet that includes chapatis, puffed rice with vegetables, multigrain bread, plain cooked dal, roasted grams soups, sprouts, cooked vegetables with less oil, steamed vegetables, orange, jamun, guava, watermelon, apple, papaya, curd, cow’s milk, thin buttermilk, fish (baked, grilled, or steamed), cashew nuts, peanuts, and walnuts (handful). Avoid alcohol consumption and quit smoking. Exercise regularly and brisk walk daily for 30 minutes. Also, limit intake of sugar.

    The risk factors for developing low blood sugar levels include not taking adequate meals or skipping meals, excessive insulin use, too much alcohol intake, fever and too much exercise. Some medications, like other diabetes medicine glimepiride, medicines used for fever and pain (salicylates), ramipril, etc., can result in such episodes when used with insulin. Inform your doctor about these episodes as you may need dose adjustment.

    Before injecting, wash your hands. Select the injection site. Clean the skin as advised. Remove outer needle cap. Spread the skin or pinch up a large area to stabilize the skin. Insert the needle as instructed. Press the knob. Remove the needle out and apply gentle pressure over the injection site for several seconds. Do not rub the area. Dispose of the needle safely by unscrewing it using the outer needle cap. Injection sites should be used alternately so that the same site is not used more than approximately once a month.

    Rotate the insulin device in the palms of your hands ten times and invert it 180° ten times immediately before use to resuspend the insulin until it appears uniformly milky or cloudy. If not, repeat the previous steps until contents are mixed. Avoid shaking vigorously as it may cause frothing which may interfere with the correct measurement of the dose. The cartridge/ device should be examined frequently and not be used if solid white particles stick to the bottom or wall of the cartridge, giving a frosted look or if clumps of material are present.

    Yes, you must prime your pen. If you do not prime, you may receive too little or too much insulin. For priming, turn the dose knob to 2 units. Hold the pen with the needle pointing up. To collect air bubbles at the top, gently tap the cartridge holder. Continue holding your pen with the needle pointing up. Push the dose knob in until it stops and '0' appears in the dose window. Hold the dose knob in and slowly count to 5. Insulin should be visible at the tip of the needle.

    To make it easier to inject, push the dose knob of the pen more slowly. It is possible that your needle is blocked. Replace the needle with a new one and prime the pen.

    The side effects of INSULIN LISPRO PROTAMINE+INSULIN LISPRO include hypoglycaemia (low blood sugar), injection site reactions, rash and itching.

    If you are experiencing any side effects, please inform your doctor.

    Medications with hyperglycemic activity (drugs that increase glucose levels) such as isoniazid, corticosteroids, certain lipid-lowering drugs (e.g., niacin), oral contraceptives, estrogens, phenothiazines, and thyroid replacement therapy may increase the insulin requirement.

    Insulin requirement may be decreased by drugs that increase insulin sensitivity or have hypoglycemic (blood sugar lowering) activity, such as oral antidiabetic agents, sulfa antibiotics, salicylates, angiotensin-converting-enzyme inhibitors, certain antidepressants (monoamine oxidase inhibitors), beta-adrenergic blockers, angiotensin II receptor blocking agents, inhibitors of pancreatic function (e.g., octreotide), and alcohol. In some patients, the symptoms of hypoglycemia (low blood sugar) may be masked by beta-adrenergic blockers.

    INSULIN LISPRO PROTAMINE+INSULIN LISPRO should be used with caution during pregnancy and lactation (breastfeeding). Follow your doctor’s instructions carefully.

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    INSULIN LISPRO+INSULIN LISPRO PROTAMINE

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