Insulin Lispro+insulin Lispro Protamine
About Insulin Lispro+insulin Lispro Protamine
Insulin Lispro Protamine+insulin Lispro is used to treat type 1 and type 2 diabetes mellitus. In diabetes mellitus type I, the body does not produce enough insulin to regulate blood sugar levels. In diabetes mellitus type II, either the body stops producing enough insulin (the hormone which helps decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, insulin is produced in large amounts, leading to high blood glucose levels.
Insulin Lispro Protamine+insulin Lispro is a combination medicine that suppress the production of sugar in the liver and facilitate the reuptake of sugar in the fat and muscle cells. Together, Insulin Lispro Protamine+insulin Lispro confirms stable sugar control.
Not everyone who is taking Insulin Lispro Protamine+insulin Lispro will get these side effects. You may experience rash, injection site allergic reaction, weight gain, edema (tissue swelling or fluid overload), skin thickening at the injection site, low blood glucose levels, and itching. Most of these side effects of Insulin Lispro Protamine+insulin Lispro do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Insulin Lispro Protamine+insulin Lispro should be taken 15 minutes before food or as advised by your doctor. It should be administered subcutaneously (in the upper thigh, abdomen, upper arm, or buttocks) only. Your doctor will explain how to inject the medicine by your own. However, if it is difficult to inject the medicine, ask a healthcare professional to administer it.
Inform your doctor if you are allergic to Insulin Lispro Protamine+insulin Lispro. Do not take Insulin Lispro Protamine+insulin Lispro if you have low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol. Try not to stop receiving Insulin Lispro Protamine+insulin Lispro of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Insulin Lispro Protamine+insulin Lispro is a cold chain medicine, and so it must be stored in the refrigerator between 2-8 degrees Celsius. Do not store in the freezer or the fridge.
Uses of Insulin Lispro+insulin Lispro Protamine
Medicinal Benefits
- Insulin Lispro Protamine+insulin Lispro belongs to the class of medications called ‘antidiabetics’ primarily used to improve blood sugar control in adults with diabetes mellitus.
- Insulin is a hormone that works by lowering glucose levels (sugar) in the blood.
- Insulin Lispro Protamine+insulin Lispro helps in improving the glycemic control, which in turn decreases the risk of progression of complications of diabetes like damage of the retina, damage to the kidney, damage to nerve cells, delayed wound healing, diabetic foot ulcer and others.
- Insulin Lispro Protamine+insulin Lispro offers the flexibility to adjust insulin intake based on carbohydrate consumption and blood glucose levels, ensuring tailored diabetes management. The
- The Penfill format facilitates precise and convenient dosing using an insulin pen device, thereby enhancing the ease of use for diabetic patients.
- Insulin Lispro Protamine+insulin Lispro starts to work within 10 minutes after injection, peaks in 2 hours and keeps working for up to 24 hours. Thereby it controls and maintains the glucose levels in the body throughout the day.
Directions for Use
- Follow your doctor's instructions carefully regarding the dosage and duration of your treatment.
- Insulin Lispro Protamine+insulin Lispro is injected under the skin. A healthcare provider can demonstrate how to properly administer the medication on your own.
- This medication should never be injected intravenously or directly into a vein.
- Avoid injecting this medicine into skin that is damaged, tender, bruised, thickened, scaly, pitted, or has scars or hard lumps.
Storage
Side Effects of Insulin Lispro+insulin Lispro Protamine
- Rashes
- Injection site allergic reaction
- Swelling
- Skin thickening at the injection site
- Low blood glucose levels
- Itching
Drug Warnings
- Inform your doctor if you are allergic to Insulin Lispro Protamine+insulin Lispro.
- Do not take Insulin Lispro Protamine+insulin Lispro if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription or recreational drugs.
- Try not to stop receiving Insulin Lispro Protamine+insulin Lispro of your own. Please inform your doctor about this, as it may cause withdrawal symptoms.
- Insulin Lispro Protamine+insulin Lispro may decrease the level of potassium, leading to a state of hypokalemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death.
- Insulin Lispro Protamine+insulin Lispro is for subcutaneous (under the skin) use only.
- If you are switching to a different insulin brand or using a different method of injection, it should be done under strict medical supervision.
- Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure.
- The first symptoms of hyperglycemia (high blood sugar levels) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and an acetone odour in the breath. You should closely monitor these symptoms.
- It is advisable not to consume alcohol, as it may either increase or decrease your blood glucose level.
- Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule.
- Insulin Lispro Protamine+insulin Lispro is a cold chain medicine, and therefore it must be stored in the refrigerator at a temperature between 2 °C and 8 °C; otherwise, its efficiency may be compromised. Do not store in the freezer or the fridge.
- Insulin Lispro Protamine+insulin Lispro should not be administered intravenously (into the vein).
Drug Interactions
Drug-Drug Interactions: Insulin Lispro Protamine+insulin Lispro may have an interaction with antidiabetics (e.g. pioglitazone), thyroid hormones (e.g. levothyroxine), blood pressure-lowering medicines (e.g. metoprolol, hydrochlorothiazide, irbesartan, candesartan), bronchodilator (e.g. metaproterenol), pain killer medications (e.g. aspirin), and anti-depressant medications (e.g. sertraline).
Drug-Food Interactions: Avoid alcoholic beverages with Insulin Lispro Protamine+insulin Lispro as it may increase or decrease your blood sugar level.
Drug-Disease Interactions: Inform your doctor before taking Insulin Lispro Protamine+insulin Lispro if you have or ever had kidney disease, hepatic impairment or liver disease, hypoglycemia (low blood sugar), and hypokalaemia (low potassium level).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended not to consume alcohol along with Insulin Lispro Protamine+insulin Lispro to avoid unpleasant side effects.
Pregnancy
consult your doctorIt is safe to use Insulin Lispro Protamine+insulin Lispro during pregnancy if prescribed by the doctor. However, consult your doctor if you have any concerns regarding this.
Breast Feeding
consult your doctorIt is safe to use Insulin Lispro Protamine+insulin Lispro by breastfeeding mothers if prescribed by the doctor. However, consult your doctor if you have any concerns regarding this.
Driving
cautionInsulin Lispro Protamine+insulin Lispro may cause hypoglycemia (low blood sugar). Therefore, drive only if you are alert.
Liver
cautionInsulin Lispro Protamine+insulin Lispro should be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.
Kidney
cautionInsulin Lispro Protamine+insulin Lispro should be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.
Children
unsafeInsulin Lispro Protamine+insulin Lispro is not approved for use by children under the age of 18.
Habit Forming
Diet & Lifestyle Advise
- Take short, frequent meals. Avoid prolonged fasting.
- Beware of hypoglycaemia symptoms such as sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience the mentioned symptoms, immediately consume 5-6 candies or three glucose biscuits or three teaspoons of honey/sugar and get in touch with your physician.
- Make sure to carry these with you at all times, especially for long travels.
- Avoid drinking alcohol. It increases the risk of hypoglycaemia (decrease in blood sugar which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts various organs).
- Try to quit smoking.
- Reduce intake of carbohydrate-rich food like potato, rice, mangoes, bread, sugar, etc.
- Avoid eating sugary food and prefer food low in calories.
- When travelling across more than two time zones, you should talk to your doctor concerning adjustments in your insulin schedule.
Special Advise
- You should undergo a test called the HbA1C (A1C) every 2-3 months to closely monitor your blood sugar level while taking Insulin Lispro Protamine+insulin Lispro.
- While using Insulin Lispro Protamine+insulin Lispro, your blood sugar level might dip, which can result in seizures or unconsciousness. You should carry a quick source of sugar (glucose tablets or sugar candies) with you if you have symptoms of low blood sugar.
- Discard the used insulin pen after 14 days, even if there is slight insulin left in it.
- Your doctor may recommend regular potassium level checks, as prolonged administration can cause a life-threatening condition of hypokalemia (low potassium levels).
- You should normally inject Insulin Lispro Protamine+insulin Lispro within 15 minutes of a meal.
Patients Concern
Disease/Condition Glossary
Type 1 diabetes mellitus: In type 1 diabetes mellitus, the body does not make insulin (the hormone that helps decrease sugar levels in the blood) to control blood sugar levels.
Type 2 diabetes mellitus: In type 2 diabetes mellitus, either the body stops producing enough insulin or there is resistance to the action of insulin. As a result, insulin is produced in sufficient amounts but cannot act on the tissues of the organs.
FAQs
Insulin Lispro Protamine+insulin Lispro is used to treat type 1 and type 2 diabetes mellitus.
Insulin Lispro Protamine+insulin Lispro suppresses the production of sugar in the liver and facilitates the reuptake of sugar in the fat and muscle cells, thereby Insulin Lispro Protamine+insulin Lispro ensures rapid and consistent sugar control.
You should inform your doctor before travelling especially when travelling to a different time zone as a dose adjustment may be required.
Hypoglycemia refers to low blood sugar levels. Insulin Lispro Protamine+insulin Lispro may cause hypoglycemia. The symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. Hypoglycemia can occur if you miss or delay your food, drink alcohol, over-exercise, or take other antidiabetic medicine along with Insulin Lispro Protamine+insulin Lispro. Therefore, it is important to monitor blood sugar levels regularly. People with diabetes are advised to keep a quick source of sugar like glucose tablets, chocolate, glucose biscuits, honey, or fruit juice with them. If you experience any of the symptoms of hypoglycemia, consult your doctor.
In some cases, Insulin Lispro Protamine+insulin Lispro can lower the potassium level, leading to a state of hypokalaemia. You may feel dizziness, thirst, and general weakness in this case. So, it is advisable to have regular blood sugar and potassium level check-up.
Do not stop taking Insulin Lispro Protamine+insulin Lispro without consulting your doctor on your own as it may cause an increase in blood glucose levels. Continue taking Insulin Lispro Protamine+insulin Lispro for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Insulin Lispro Protamine+insulin Lispro.
You are recommended to avoid white bread, maida, poori, naan, noodles, biryani, fried rice, corn flakes, cheese, ice creams, milkshakes, beef, pork, sugarcane juice, soft drinks, sweetened health drinks and beverages. Also, avoid mango, seetaphal, jack fruit, fruit salads with ice cream, and fruit-based desserts.
Taking injection at the same site may cause local irritation, itching and lump formation. Therefore, it is best to avoid taking injections at the same site or maintain a gap of at least one day.
Maintain a diet that includes chapatis, puffed rice with vegetables, multigrain bread, plain cooked dal, roasted grams soups, sprouts, cooked vegetables with less oil, steamed vegetables, orange, jamun, guava, watermelon, apple, papaya, curd, cow’s milk, thin buttermilk, fish (baked, grilled, or steamed), cashew nuts, peanuts, and walnuts (handful). Avoid alcohol consumption and quit smoking. Exercise regularly and brisk walk daily for 30 minutes. Also, limit intake of sugar.
The risk factors for developing low blood sugar levels include not taking adequate meals or skipping meals, excessive insulin use, too much alcohol intake, fever and too much exercise. Some medications, like other diabetes medicine glimepiride, medicines used for fever and pain (salicylates), ramipril, etc., can result in such episodes when used with insulin. Inform your doctor about these episodes as you may need dose adjustment.
Before injecting, wash your hands. Select the injection site. Clean the skin as advised. Remove outer needle cap. Spread the skin or pinch up a large area to stabilize the skin. Insert the needle as instructed. Press the knob. Remove the needle out and apply gentle pressure over the injection site for several seconds. Do not rub the area. Dispose of the needle safely by unscrewing it using the outer needle cap. Injection sites should be used alternately so that the same site is not used more than approximately once a month.
Rotate the insulin device in the palms of your hands ten times and invert it 180° ten times immediately before use to resuspend the insulin until it appears uniformly milky or cloudy. If not, repeat the previous steps until contents are mixed. Avoid shaking vigorously as it may cause frothing which may interfere with the correct measurement of the dose. The cartridge/ device should be examined frequently and not be used if solid white particles stick to the bottom or wall of the cartridge, giving a frosted look or if clumps of material are present.
Yes, you must prime your pen. If you do not prime, you may receive too little or too much insulin. For priming, turn the dose knob to 2 units. Hold the pen with the needle pointing up. To collect air bubbles at the top, gently tap the cartridge holder. Continue holding your pen with the needle pointing up. Push the dose knob in until it stops and '0' appears in the dose window. Hold the dose knob in and slowly count to 5. Insulin should be visible at the tip of the needle.
To make it easier to inject, push the dose knob of the pen more slowly. It is possible that your needle is blocked. Replace the needle with a new one and prime the pen.
The side effects of Insulin Lispro Protamine+insulin Lispro include hypoglycaemia (low blood sugar), injection site reactions, rash and itching.
If you are experiencing any side effects, please inform your doctor.
Medications with hyperglycemic activity (drugs that increase glucose levels) such as isoniazid, corticosteroids, certain lipid-lowering drugs (e.g., niacin), oral contraceptives, estrogens, phenothiazines, and thyroid replacement therapy may increase the insulin requirement.
Insulin requirement may be decreased by drugs that increase insulin sensitivity or have hypoglycemic (blood sugar lowering) activity, such as oral antidiabetic agents, sulfa antibiotics, salicylates, angiotensin-converting-enzyme inhibitors, certain antidepressants (monoamine oxidase inhibitors), beta-adrenergic blockers, angiotensin II receptor blocking agents, inhibitors of pancreatic function (e.g., octreotide), and alcohol. In some patients, the symptoms of hypoglycemia (low blood sugar) may be masked by beta-adrenergic blockers.
Insulin Lispro Protamine+insulin Lispro should be used with caution during pregnancy and lactation (breastfeeding). Follow your doctor’s instructions carefully.
